https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52688 Wed 28 Feb 2024 15:49:25 AEDT ]]> Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51924 Wed 28 Feb 2024 09:57:50 AEDT ]]> Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47714 Wed 25 Jan 2023 11:52:16 AEDT ]]> Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in copd: implications for disease progression and new therapeutics https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37130 Wed 19 Aug 2020 12:59:44 AEST ]]> Adverse roles of mast cell chymase-1 in COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53957 Tue 23 Jan 2024 10:53:40 AEDT ]]> Impact of Deleterious Mutations on Structure, Function and Stability of Serum/Glucocorticoid Regulated Kinase 1: A Gene to Diseases Correlation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53288 Tue 21 Nov 2023 10:30:38 AEDT ]]> Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43418 Tue 20 Sep 2022 08:26:35 AEST ]]> ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46351 n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. Results: Increased gene expression of ACE2 was associated with older age (P = 0.03) and male sex (P = 0.03), but not with pack-years smoked. When we compared gene expression between adults with asthma, COPD and healthy controls, mean ACE2 expression was lower in asthma patients (P = 0.01). Gene expression of furin, a protease that facilitates viral endocytosis, was also lower in patients with asthma (P = 0.02), while ADAM-17, a disintegrin that cleaves ACE2 from the surface, was increased (P = 0.02). ACE2 protein expression was also reduced in endobronchial biopsies from asthma patients. Conclusion: Increased ACE2 expression occurs in older people and males. Asthma patients have reduced expression. Altered ACE2 expression in the lower airway may be an important factor in virus tropism and may in part explain susceptibility factors and why asthma patients are not over-represented in those with COVID-19 complications.]]> Tue 15 Nov 2022 15:15:58 AEDT ]]> Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38305 Thu 26 Aug 2021 11:11:37 AEST ]]>